Description

[2H5]-Quinapril is a stable isotope-labeled analog of the angiotensin-converting enzyme (ACE) inhibitor quinapril, specifically deuterated at five positions. This compound is a critical internal standard for the precise quantification of quinapril in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is an essential tool for pharmaceutical research and development, clinical pharmacology, and bioanalytical laboratories requiring the highest level of accuracy in pharmacokinetic and metabolic studies.

Application

• Quantitative Bioanalysis: Serves as a primary internal standard for the accurate measurement of quinapril concentrations in plasma, serum, and tissue samples via mass spectrometry.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables reliable tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Metabolite Identification and Profiling: Used in stable isotope dilution assays to identify and quantify quinapril metabolites, aiding in understanding its metabolic pathways.
• Method Development and Validation: Critical for developing, optimizing, and validating robust LC-MS/MS methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Manufacturing: Can be utilized in impurity profiling and assay validation during the drug manufacturing process to ensure product consistency.
• Forensic and Doping Analysis: Supports precise detection and confirmation of quinapril in forensic toxicology and anti-doping control programs.

Basic Information

Product Name	[2H5]-Quinapril
CAS No.	1279029-79-6
Molecular Formula	C25H25D5N2O5
Molecular Weight	~447.53 g/mol
Synonyms	Quinapril-d5; Deuterated Quinapril; [2,3,4,5,6-2H5]-Quinapril; (3S)-2-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid-d5; 1H-Isoquinoline-3-carboxylic acid, 2-[(2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, (3S)-, pentadeuterated; Acequin-d5; Accupril-d5 (labeled analog)
EINECS	Contact for details

Quality Control

Every batch of [2H5]-Quinapril is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic purity (atom % D), and absence of critical impurities. Our quality commitment ensures reliability for your most sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.