Description

Cinnarizine-D8 2Hcl (Piperazine-D8) is a deuterium-labeled analog of the pharmaceutical compound Cinnarizine, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities for pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the precise quantification of Cinnarizine and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Serves as a stable, non-interfering reference to establish robust, reproducible, and regulatory-compliant analytical assays.
• Pharmaceutical Quality Control: Used in impurity profiling and stability studies to monitor the active pharmaceutical ingredient (API).
• Forensic and Clinical Toxicology: Assists in the accurate detection and quantification of Cinnarizine in forensic investigations or therapeutic drug monitoring.

Basic Information

Product Name	Cinnarizine-D8 2Hcl (Piperazine-D8)
CAS No.	1276545-36-8
Molecular Formula	C26H20D8Cl2N2 • 2HCl
Molecular Weight	~ 492.34 g/mol (for monoisotopic mass)
Synonyms	1-(Diphenylmethyl)-4-(3-phenyl-2-propen-1-yl)-piperazine-d8 Dihydrochloride; 1-Benzhydryl-4-cinnamyl-piperazine-d8 Dihydrochloride; Cinnarizine-d8 Dihydrochloride; Cinnarizine (piperazine-d8) Dihydrochloride; Cinnarizine (phenyl-d5, piperazine-d8) Dihydrochloride; Cinnarizine D8; CZ-D8
EINECS	Contact for details

Quality Control

Every batch of Cinnarizine-D8 2Hcl is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail critical parameters including isotopic purity (chemical and isotopic), chromatographic purity, and residual solvent content. Our quality protocols are designed to meet the stringent requirements of GMP/GLP-compliant laboratories, ensuring data integrity for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity (by NMR)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.