Description

2,3,5,6-Tetradeuterio-4-[5-[4-(Hydroxymethyl)Phenyl]-3-(Trifluoromethyl)Pyrazol-1-Yl]Benzenesulfonamide is a deuterated analog of a key benzenesulfonamide derivative, offering enhanced metabolic stability and pharmacokinetic properties for advanced research. This compound is critical for use as an internal standard in quantitative mass spectrometry, ensuring high-fidelity analytical results in method development and validation. It is primarily utilized by pharmaceutical R&D teams and analytical laboratories engaged in drug discovery, metabolism studies, and bioanalytical method development.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification of the non-deuterated parent drug in complex biological matrices.
• Mass Spectrometry Internal Standard: Essential for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) to improve accuracy and precision in pharmacokinetic and bioequivalence studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track drug candidates and their metabolites.
• Analytical Method Development: Aids in the development and validation of robust, sensitive, and specific analytical methods for regulatory submissions.
• Isotope Dilution Analysis: Enables precise quantification in clinical research and forensic toxicology where high accuracy is paramount.
• Biochemical Research: Used as a probe in enzyme inhibition assays and receptor binding studies involving sulfonamide-based targets.

Basic Information

Product Name	2,3,5,6-Tetradeuterio-4-[5-[4-(Hydroxymethyl)Phenyl]-3-(Trifluoromethyl)Pyrazol-1-Yl]Benzenesulfonamide
CAS No.	1276524-56-1
Molecular Formula	C17H10D4F3N3O3S
Molecular Weight	409.39 g/mol (for the deuterated form)
Synonyms	Deuterated Celecoxib-d4 (hydroxymethyl analog); 4-[5-(4-Hydroxymethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide-d4; Celecoxib-d4 derivative; Tetradeuterated benzenesulfonamide pyrazole; 1-[4-(Aminosulfonyl)phenyl]-5-(4-(hydroxymethyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-2,3,5,6-d4; [2,3,5,6-2H4]-4-[5-[4-(Hydroxymethyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is produced and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, with comprehensive testing including HPLC for chemical purity and NMR/MS for isotopic purity verification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. Our quality commitment aligns with the standards expected for pharmaceutical research and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.