Description

Adapalene-D3 is a deuterated isotopologue of the well-known retinoid Adapalene, specifically designed for use as an internal standard in analytical chemistry. This high-purity reference material is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmaceutical research and quality control. It is an essential tool for scientists and quality assurance professionals in the pharmaceutical, contract research organization (CRO), and analytical testing industries who require precise measurement of Adapalene in complex matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the precise quantification of Adapalene in bioanalytical studies, pharmacokinetic research, and method validation.
• Pharmaceutical R&D: Used in the development and validation of analytical methods for new drug formulations containing Adapalene, ensuring method robustness and regulatory compliance.
• Quality Control (QC) Testing: Employed in pharmaceutical manufacturing QC labs to accurately determine the concentration of Adapalene in active pharmaceutical ingredients (APIs) and finished topical products (e.g., gels, creams).
• Metabolite Studies: Facilitates the identification and quantification of Adapalene metabolites in biological samples during drug metabolism and pharmacokinetics (DMPK) studies.
• Stability Indicating Methods: Integral to assays designed to monitor the stability and degradation profile of Adapalene under various storage conditions.
• Regulatory Submissions: Supports data packages submitted to regulatory bodies (e.g., FDA, EMA) by providing traceable and definitive quantitative results.

Basic Information

Product Name	Adapalene-D3
CAS No.	1276433-89-6
Molecular Formula	C28H25D3O3
Molecular Weight	415.55 g/mol (approx.)
Synonyms	6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic-2,4,5-d3 Acid; Deuterated Adapalene; Adapalene-d3; CD 271-d3; Diferin-d3; ADA-d3; Isotopically Labeled Adapalene; (6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthalenecarboxylic-2,4,5-d3 Acid)
EINECS	Contact for details

Quality Control

Every batch of Adapalene-D3 is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing critical parameters such as isotopic purity, chemical purity, and identity confirmation. Our quality commitment ensures the material meets the stringent requirements for use in regulated analytical environments, supporting GLP and GMP compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.