Description

(2Rs,3Rs)-3-(2-Ethoxy-D5-Phenoxy)-1,2-Dihydroxy-3-Phenylpropane is a high-purity, deuterated chemical building block of significant interest in advanced research and development. Its core value lies in its utility as a labeled intermediate for the synthesis of novel compounds, enabling critical studies in pharmacokinetics, metabolism, and tracer analysis. This product is essential for pharmaceutical researchers, analytical chemists, and material scientists working in drug discovery, process chemistry, and the development of deuterated active pharmaceutical ingredients (APIs).

Application

• Deuterated Pharmaceutical Intermediate: Serves as a key labeled precursor in the synthesis of deuterium-enriched drug candidates for improved metabolic stability and pharmacokinetic profiling.
• Metabolic Tracer Studies: Used in the development of internal standards and tracers for mass spectrometry (LC-MS, GC-MS) to study drug metabolism and bioavailability.
• Organic Synthesis Building Block: Employed in sophisticated multi-step organic syntheses requiring a specific stereochemistry and deuterium labeling.
• Research & Development: Critical for academic and industrial R&D projects focused on isotopically labeled compounds, mechanistic studies, and novel chemical entity development.
• Process Chemistry & Scale-up: Supports route scouting and optimization for the production of deuterated target molecules at various scales.

Basic Information

Product Name	(2Rs,3Rs)-3-(2-Ethoxy-D5-Phenoxy)-1,2-Dihydroxy-3-Phenylpropane
CAS No.	1276340-65-8
Molecular Formula	C17H13D5O4
Molecular Weight	295.36 g/mol
Synonyms	1,2-Dihydroxy-3-(2-ethoxy-d5-phenoxy)-3-phenylpropane (2R,3R)-isomer; (2R,3R)-3-(2-Ethoxy-d5-phenoxy)-1,2-dihydroxy-3-phenylpropane; Deuterated Dihydroxy Phenylpropane Derivative; (2R,3R)-D5-Ethoxy Phenoxy Phenylpropane Diol; 3-Phenyl-3-[2-(1,1,2,2,2-pentadeuteroethoxy)phenoxy]propane-1,2-diol (2R,3R)-form
EINECS	Contact for details

Quality Control

Our (2Rs,3Rs)-3-(2-Ethoxy-D5-Phenoxy)-1,2-Dihydroxy-3-Phenylpropane is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity, isotopic enrichment (D5), chiral purity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Isotopic Enrichment (D5, MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.