Description

Thiorphan-D7 is a deuterated analog of the potent enkephalinase inhibitor Thiorphan, specifically labeled with seven deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require precise pharmacokinetic and metabolic studies.

Application

• Primary use as an internal standard for the quantification of Thiorphan in biological matrices via LC-MS/MS and GC-MS.
• Facilitates drug metabolism and pharmacokinetics (DMPK) studies in preclinical and clinical research.
• Enables accurate bioanalytical method development and validation for regulatory submissions.
• Supports research into the enkephalinase enzyme system and neuropharmacology.
• Used in isotope dilution analysis to achieve superior precision in trace-level detection.
• Critical for ensuring data integrity in Good Laboratory Practice (GLP) and Good Clinical Practice (GCP) compliant laboratories.

Basic Information

Product Name	Thiorphan-D7
CAS No.	1276297-68-7
Molecular Formula	C13H10D7NO4S
Molecular Weight	284.36 g/mol
Synonyms	N-[(R,S)-2-Benzyl-3,3,3-d3-mercaptopropionyl-d4]glycine; (R,S)-N-(2-Benzyl-3-mercaptopropanoyl)glycine-d7; DL-Thiorphan-d7; (±)-Thiorphan-d7; Enkephalinase Inhibitor-d7; Racemic Thiorphan-d7; N-[(RS)-2-Benzyl-3-mercaptopropionyl]glycine-d7
EINECS	Contact for details

Quality Control

Every batch of Thiorphan-D7 is manufactured and analyzed under strict quality systems to ensure identity, purity, and isotopic enrichment meet the exacting standards required for analytical applications. We provide comprehensive Certificates of Analysis (COA) detailing results from advanced techniques including NMR, HPLC, and mass spectrometry. Our commitment to cGMP principles and supply chain traceability guarantees the consistency and reliability essential for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.