Description

D-2-Aminobutyric-D6 Acid CAS NO 1276197-57-9 is a stable isotope-labeled analog of the non-proteinogenic amino acid D-2-aminobutyric acid, where six hydrogen atoms are replaced by deuterium. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring precise and accurate analytical measurements. It is primarily required by pharmaceutical, biotechnology, and contract research organizations (CROs) for advanced pharmacokinetic, metabolomic, and proteomic studies.

Application

• Mass Spectrometry Internal Standard: Critical for the accurate quantification of D-2-aminobutyric acid and related metabolites in complex biological matrices via LC-MS/MS and GC-MS.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) of drug candidates.
• Metabolomics Research: Enables precise measurement of amino acid flux and metabolic pathway analysis in disease state investigations.
• Biomarker Discovery & Validation: Serves as a stable isotope reference for developing and validating clinical diagnostic assays.
• Quality Control in API Synthesis: Acts as a tracer or reference material in the synthesis and purity assessment of chiral pharmaceutical intermediates.
• Neuroscience Research: Utilized in studies investigating the role of D-amino acids and their derivatives in neurological function and disorders.

Basic Information

Product Name	D-2-Aminobutyric-D6 Acid
CAS No.	1276197-57-9
Molecular Formula	C₄H₃D₆NO₂
Molecular Weight	121.17 g/mol
Synonyms	(2R)-2-Amino[3,3,4,4,5,5-D6]butanoic Acid; D-α-Aminobutyric-D6 Acid; (R)-2-Aminobutyric-D6 Acid; D-2-Aminobutanoic-D6 Acid; D-Homoalanine-D6; (R)-2-Amino-D6-butyric Acid; Deuterated D-2-AB; D-2-AB-D6
EINECS	Contact for details

Quality Control

Our D-2-Aminobutyric-D6 Acid is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity for critical analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (Atom % D), chiral purity, chemical purity by HPLC, and residual solvent content. We adhere to relevant industry standards for high-purity reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions after opening to maintain stability and purity. Keep the container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0% (by MS)
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.