Description

α-Hydroxymetoprolol-D7 (iso-Propyl-D7) (Mixture Of Stereoisomers) is a deuterated isotopologue of a key hydroxymetoprolol metabolite, specifically labeled on the isopropyl group. This compound is essential for use as a high-purity internal standard in quantitative bioanalytical methods, such as LC-MS/MS, ensuring accurate and reliable pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on cardiovascular drug development and regulatory compliance.

Application

• Internal Standard for Bioanalysis: Critical for the precise quantification of metoprolol and its metabolites in biological matrices (plasma, serum, urine) using mass spectrometry.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles.
• Clinical Trial Support: Used in the bioanalytical phase of clinical trials to ensure data integrity for regulatory submissions to agencies like the FDA and EMA.
• Metabolite Reference Standard: Serves as an authenticated reference material for the identification and characterization of the α-hydroxymetoprolol metabolite.
• Forensic and Sports Toxicology: Supports accurate testing for metoprolol in forensic investigations or anti-doping controls.
• Method Development and Validation: A key component in developing, optimizing, and validating robust LC-MS/MS assays in compliance with GLP guidelines.

Basic Information

Product Name	α-Hydroxymetoprolol-D7 (iso-Propyl-D7) (Mixture Of Stereoisomers)
CAS No.	1276197-39-7
Molecular Formula	C15H18D7NO4
Molecular Weight	~ 284.40 g/mol
Synonyms	1-(Isopropyl-d7-amino)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol; Metoprolol Metabolite Hydroxy-D7; α-Hydroxymetoprolol-d7; 1'-(Isopropyl-d7)-α-hydroxymetoprolol; Dextro/Levo-α-Hydroxymetoprolol-D7; (RS)-α-Hydroxymetoprolol-(isopropyl-d7); H 119/66-d7 (hydroxy metabolite); Lopressor Metabolite-D7
EINECS	Contact for details

Quality Control

Every batch of α-Hydroxymetoprolol-D7 (iso-Propyl-D7) is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, confirmed by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for identity, purity (HPLC assay), isotopic enrichment (D-content), and impurity profiles. Our quality commitment supports compliance with GMP/GLP principles for use in regulated studies.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.