Description

(±)-Atropine-D3 (n-Methyl-D3) CAS NO 1276197-36-4 is a deuterated isotopologue of the classic anticholinergic alkaloid atropine, where three hydrogen atoms on the N-methyl group are replaced by deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and precision in analytical workflows. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and forensic toxicology units for method development, pharmacokinetic studies, and drug metabolism investigations.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of atropine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic and Clinical Toxicology: Used in confirmatory testing for atropine or scopolamine poisoning, providing legally defensible analytical results.
• Drug Metabolism Research: Facilitates the identification and quantification of metabolite profiles in in vitro and in vivo studies.
• Pharmaceutical Quality Control: Supports analytical method validation for atropine-containing drug formulations to ensure batch consistency and purity.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the reference material in this gold-standard technique for achieving the highest measurement accuracy.

Basic Information

Product Name	(±)-Atropine-D3 (n-Methyl-D3)
CAS No.	1276197-36-4
Molecular Formula	C17H20D3NO3
Molecular Weight	292.40 g/mol (approx.)
Synonyms	Atropine-d3 (N-methyl-d3); DL-Hyoscyamine-d3 (N-methyl-d3); 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate-d3; Tropine tropate-d3; (±)-Tropanyl (±)-tropate-d3; Endotropin-d3; Stable Isotope Labeled Atropine; Atropine Internal Standard
EINECS	Contact for details

Quality Control

Every batch of (±)-Atropine-D3 (n-Methyl-D3) is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, confirmed by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA), detailing assay, isotopic enrichment (D3), and impurity profile, is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.