Description

5-Hydroxy-L-Tryptophan-4,6,7-D3 is a deuterium-labeled isotopologue of the essential amino acid derivative 5-Hydroxytryptophan (5-HTP). This compound is a critical analytical standard and internal reference material, enabling precise quantification and metabolic pathway tracing in sophisticated research. It is primarily utilized by pharmaceutical R&D, contract research organizations (CROs), and academic institutions engaged in advanced analytical chemistry. The product is essential for ensuring accuracy and reliability in studies involving neurotransmitter synthesis, pharmacokinetics, and stable isotope labeling.

Application

• Internal Standard for LC-MS/MS and GC-MS Analysis: Provides unmatched accuracy for quantifying endogenous 5-HTP and related metabolites in complex biological matrices like plasma, serum, and cerebrospinal fluid.
• Stable Isotope-Labeled Tracer in Metabolic Studies: Used to elucidate the biosynthesis and turnover rates of serotonin and melatonin in neurological and endocrine research.
• Pharmaceutical Impurity Profiling and Method Development: Serves as a critical reference compound for validating analytical methods in drug development, particularly for 5-HTP-based nutraceuticals or therapeutics.
• Deuterated Reference Material for NMR Spectroscopy: Aids in structural elucidation and reaction monitoring where non-exchangeable deuterium labels are required.
• Quality Control and Assurance in API Manufacturing: Ensures batch-to-batch consistency and purity assessment for manufacturers of high-grade 5-HTP.

Basic Information

Product Name	5-Hydroxy-L-Tryptophan-4,6,7-D3
CAS No.	1276197-29-5
Molecular Formula	C11H9D3N2O3
Molecular Weight	223.23 g/mol (approximate)
Synonyms	5-HTP-d3; L-5-Hydroxytryptophan-4,6,7-d3; (2S)-2-Amino-3-(5-hydroxy-4,6,7-trideuterio-1H-indol-3-yl)propanoic acid; 5-Hydroxy-DL-tryptophan-4,6,7-d3; Oxitriptan-d3; 5-HTP-D3 Internal Standard; Deuterated 5-Hydroxytryptophan
EINECS	Contact for details

Quality Control

Our 5-Hydroxy-L-Tryptophan-4,6,7-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D3), chemical purity by HPLC, and confirmation of structure. We adhere to relevant industry standards for reference materials, and custom synthesis to meet specific purity or enrichment specifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D (D3)
Chemical Purity	≥ 95% (by HPLC, area%)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.