Description

Chlorpromazine-(Dimethyl-D6) Oxalate is a stable isotope-labeled analog of the antipsychotic drug chlorpromazine, where six hydrogen atoms are replaced by deuterium at the dimethylamino group. This high-purity reference standard is critical for ensuring accuracy and reliability in quantitative bioanalytical studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced pharmacokinetics, metabolism research, and method development using mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Serves as a crucial internal standard for the precise quantification of chlorpromazine and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for studying the absorption, distribution, metabolism, and excretion (ADME) profile of chlorpromazine in preclinical and clinical research.
• Forensic and Clinical Toxicology: Used in analytical methods for the accurate detection and confirmation of chlorpromazine in forensic investigations and therapeutic drug monitoring.
• Pharmaceutical Impurity Profiling: Aids in the identification and characterization of process-related impurities and degradation products during drug development and quality control.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy IDMS techniques, which are considered a gold standard for reference measurement procedures in clinical chemistry.
• Stable Isotope Labeling Studies: Facilitates mechanistic studies of metabolic pathways and the differentiation between administered drug and endogenous compounds.

Basic Information

Product Name	Chlorpromazine-(Dimethyl-D6) Oxalate
CAS No.	1276197-23-9
Molecular Formula	C19H17D6ClN2S • C2H2O4
Molecular Weight	443.97 g/mol
Synonyms	Chlorpromazine-d6 Oxalate; 2-Chloro-10-[3-(dimethyl-d6-amino)propyl]phenothiazine Oxalate; 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-bis(methyl-d3)propan-1-amine Oxalate; Largactil-d6 Oxalate; CPZ-d6 Oxalate; Deuterated Chlorpromazine Oxalate; Chlorpromazine (N,N-dimethyl-d6) Oxalate
EINECS	Contact for details

Quality Control

Every batch of Chlorpromazine-(Dimethyl-D6) Oxalate is manufactured and analyzed under strict quality management systems. The product undergoes rigorous testing to ensure compliance with the highest standards for isotopic purity and chemical purity, suitable for use as a certified reference material. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, isotopic enrichment, and impurity profiles as determined by advanced analytical techniques including NMR, HPLC, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.