Description

2,5-Bis(1,1-Dideuterio-2,2,2-Trifluoroethoxy)-n-(Piperidin-2-Ylmethyl)Benzamide is a sophisticated deuterated and fluorinated benzamide derivative, designed for advanced research and development. This compound is of significant value for its role as a stable isotope-labeled intermediate or active pharmaceutical ingredient (API) in the development of novel therapeutics. It is primarily needed by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in drug discovery, particularly in areas like metabolic studies, pharmacokinetics, and bioanalytical method development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of deuterated drug candidates for improved metabolic stability and pharmacokinetic profiles.
• Metabolic Tracer: Used in mass spectrometry-based studies to track drug metabolism and distribution due to its deuterium labels.
• Protease/Enzyme Inhibitor Research: The piperidinylmethyl-benzamide structure suggests potential application in the development of enzyme inhibitors for various disease targets.
• Reference Standard: Employed as a high-purity analytical standard for quality control and quantification in bioanalytical assays.
• Medicinal Chemistry: A key scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Nuclear Magnetic Resonance (NMR) Studies: The deuterium atoms provide a useful probe for advanced NMR spectroscopic analysis in structural biology.

Basic Information

Product Name	2,5-Bis(1,1-Dideuterio-2,2,2-Trifluoroethoxy)-n-(Piperidin-2-Ylmethyl)Benzamide
CAS No.	1276197-20-6
Molecular Formula	C18H17D4F6N2O3
Molecular Weight	439.39 g/mol
Synonyms	2,5-Bis(1,1-dideuterio-2,2,2-trifluoroethoxy)-N-(piperidin-2-ylmethyl)benzamide; Benzamide, 2,5-bis(1,1-dideuterio-2,2,2-trifluoroethoxy)-N-(2-piperidinylmethyl)-; Deuterated Trifluoroethoxy Benzamide Piperidine Derivative; 1276197-20-6; N-[(Piperidin-2-yl)methyl]-2,5-bis(1,1-dideuterio-2,2,2-trifluoroethoxy)benzamide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material that meets high-purity specifications suitable for research and development. Certificates of Analysis (COA) detailing identity, purity (typically by HPLC), and impurity profiles are available upon request. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Deuterium Incorporation (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.