Description

(±)-n-(2,6-Dimethylphenyl)-1-iso-Propyl-D7-2-Piperidinecarboxamide CAS NO 1276197-11-5 is a high-purity, deuterated isotopologue of a key pharmaceutical intermediate. This compound is specifically engineered for use in advanced research and development, offering enhanced metabolic stability and traceability in pharmacokinetic and pharmacodynamic studies. It is an essential building block for medicinal chemists and analytical scientists working in drug discovery, particularly for developing and validating novel central nervous system (CNS) agents and anesthetics.

Application

• Deuterated Internal Standard for LC-MS/MS: Critical for the precise quantitative analysis of its non-deuterated counterpart in complex biological matrices during bioanalytical method development.
• Metabolic Pathway Tracing: Used in drug metabolism and disposition (DMPK) studies to investigate metabolic stability, identify metabolites, and understand clearance mechanisms.
• Pharmaceutical R&D Reference Standard: Serves as a certified reference material for quality control and method validation in the synthesis of novel anesthetic and analgesic compounds.
• Isotope Dilution Mass Spectrometry: Enables highly accurate and sensitive quantification in pharmacokinetic studies, improving data reliability for regulatory submissions.
• Mechanistic Studies in Medicinal Chemistry: Facilitates research into the structure-activity relationships (SAR) of piperidinecarboxamide derivatives by providing a metabolically stable analog.

Basic Information

Product Name	(±)-n-(2,6-Dimethylphenyl)-1-iso-Propyl-D7-2-Piperidinecarboxamide
CAS No.	1276197-11-5
Molecular Formula	C17H19D7N2O
Molecular Weight	277.45 g/mol
Synonyms	1-Isopropyl-D7-2',6'-Pipecoloxylidide; Ropivacaine-D7; Ropivacaine (heptadeutero, isopropyl-d7); (±)-1-Propyl-D7-2',6'-pipecoloxylidide; 1-(1-Methylethyl-d7)-2',6'-pipecoloxylidide; N-(2,6-Dimethylphenyl)-1-(propan-2-yl-d7)piperidine-2-carboxamide; Deuterated Ropivacaine Intermediate; 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-(1-methylethyl-d7)-, (±)-
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR (1H, 13C), Mass Spectrometry, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment (D-content), and solvent residues. Our standards align with the requirements for research and reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product under an inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.