Description

5-(2-Fluoro-5-Methylphenyl)Indoline is a high-purity, advanced pharmaceutical intermediate featuring a unique indoline scaffold substituted with a fluorinated aromatic ring. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modulation. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities for oncology, central nervous system (CNS) disorders, and other specialized treatments.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and novel APIs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fluorinated Compound Synthesis: The fluorine atom and methyl group on the phenyl ring make it a valuable synthon for introducing specific pharmacokinetic and binding properties into target molecules.
• Agrochemical Development: Potential use as an intermediate in the research and development of new generation agrochemicals and pesticides.
• Material Science Research: Can be investigated as a monomer or building block for specialty polymers and advanced organic materials.

Basic Information

Product Name	5-(2-Fluoro-5-Methylphenyl)Indoline
CAS No.	1275402-77-1
Molecular Formula	C15H14FN
Molecular Weight	227.28 g/mol
Synonyms	5-(2-Fluoro-5-methylphenyl)-2,3-dihydro-1H-indole; 2,3-Dihydro-5-(2-fluoro-5-methylphenyl)-1H-indole; 1H-Indole, 2,3-dihydro-5-(2-fluoro-5-methylphenyl)-; 5-(2-Fluoro-5-methylphenyl)indoline; Indoline, 5-(2-fluoro-5-methylphenyl)-
EINECS	Contact for details

Quality Control

Our 5-(2-Fluoro-5-Methylphenyl)Indoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.