Description

cis-Halofuginone is a specific stereoisomer of the antiprotozoal and anti-fibrotic compound Halofuginone. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the synthesis of targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in developing treatments for fibrotic diseases, parasitic infections, and as a biochemical tool for studying amino acid metabolism.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced Halofuginone-based drug candidates for clinical research.
• Anti-Fibrotic Research: Used as a reference standard and active material in studies targeting collagen synthesis inhibition for conditions like scleroderma, liver fibrosis, and keloid scarring.
• Veterinary Medicine Development: Serves as a precursor in formulating coccidiostats and antiprotozoal treatments for livestock and poultry.
• Biochemical Pathway Inhibition: Employed in laboratory settings to study the inhibition of prolyl-tRNA synthetase and its effects on amino acid metabolism and T-cell differentiation.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC/QA) of related pharmaceutical products.

Basic Information

Product Name	cis-Halofuginone
CAS No.	1273594-72-1
Molecular Formula	C₁₆H₁₇BrClN₃O₃
Molecular Weight	414.68 g/mol
Synonyms	7-Bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxy-2-piperidyl]-2-oxopropyl]-4(3H)-quinazolinone; Halofuginone (cis-isomer); RU-19110 (cis); Febrifugine derivative; NSC-713689; trans-Halofuginone isomer; (2S,3R)-Halofuginone
EINECS	Contact for details

Quality Control

Our cis-Halofuginone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.