Description

Racemic-(1S,3S,4S,5R)-2-tert-Butyl 3-Ethyl 5-Hydroxy-2-Azabicyclo[2.2.2]Octane-2,3-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex, rigid bicyclic structure. This compound is a critical chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and antiviral therapeutics. It is essential for research institutions and pharmaceutical manufacturers engaged in process development and the production of complex, stereochemically defined molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting neurological pathways.
• Asymmetric Synthesis: Utilized as a scaffold or precursor in catalytic asymmetric reactions to introduce stereochemical complexity.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing molecular libraries and exploring structure-activity relationships (SAR) in drug discovery.
• Process Chemistry & Scale-Up: Used in the development and optimization of robust, scalable synthetic routes for API manufacturing under GMP conditions.
• Protease Inhibitor Development: Potential application as a core structure in the design of inhibitors for various protease enzymes.
• Academic & Industrial R&D: Employed in fundamental organic chemistry research and the development of new synthetic methodologies.

Basic Information

Product Name	Racemic-(1S,3S,4S,5R)-2-tert-Butyl 3-Ethyl 5-Hydroxy-2-Azabicyclo[2.2.2]Octane-2,3-Dicarboxylate
CAS No.	1272756-98-5
Molecular Formula	C16H27NO5
Molecular Weight	313.39 g/mol
Synonyms	2-Azabicyclo[2.2.2]octane-2,3-dicarboxylic acid, 5-hydroxy-, 2-(1,1-dimethylethyl) 3-ethyl ester, (1S,3S,4S,5R)-rel-; rel-(1S,3S,4S,5R)-2-tert-Butyl 3-ethyl 5-hydroxy-2-azabicyclo[2.2.2]octane-2,3-dicarboxylate; (±)-(1S,3S,4S,5R)-2-tert-Butyl 3-ethyl 5-hydroxy-2-azabicyclo[2.2.2]octane-2,3-dicarboxylate; 2-Azabicyclo[2.2.2]octane-2,3-dicarboxylic acid, 5-hydroxy-, 1-(1,1-dimethylethyl) 3-ethyl ester, (1α,3α,4α,5β)-; Bicyclic amino ester intermediate; tert-Butyl ethyl 5-hydroxy-2-azabicyclo[2.2.2]octane-2,3-dicarboxylate
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Quality Control

Our Racemic-(1S,3S,4S,5R)-2-tert-Butyl 3-Ethyl 5-Hydroxy-2-Azabicyclo[2.2.2]Octane-2,3-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure high chemical and isomeric purity suitable for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99:1 dr (specified diastereomers)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.