Description

5-Pyrrolidin-2-Ylthiophene-2-Carboxylic Acid Hydrochloride is a high-purity organic building block and pharmaceutical intermediate of significant commercial and research interest. Its value lies in its unique heterocyclic structure, which combines a thiophene core with a pyrrolidine moiety, making it a versatile scaffold for medicinal chemistry and advanced material synthesis. This compound is primarily sought by R&D laboratories and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Medicinal Chemistry Research: Serves as a critical building block for constructing compound libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Agrochemical Development: Used in the research and synthesis of new pesticides and herbicides, leveraging its heterocyclic framework for bioactivity.
• Chemical Biology Probes: Employed in the development of molecular probes and tools for studying biological pathways and enzyme functions.
• Material Science: Potential monomer or precursor for synthesizing specialty polymers and organic electronic materials with unique conductive or optical properties.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	5-Pyrrolidin-2-Ylthiophene-2-Carboxylic Acid Hydrochloride
CAS No.	1269054-05-8
Molecular Formula	C9H12ClNO2S
Molecular Weight	233.71 g/mol
Synonyms	2-(Thiophen-2-yl)-1-pyrrolidinecarboxylic acid hydrochloride; 5-(Pyrrolidin-2-yl)thiophene-2-carboxylic acid hydrochloride; 2-(2-Carboxythiophen-5-yl)pyrrolidine hydrochloride; 2-Thiophenepyrrolidine-2-carboxylic acid hydrochloride; (S)-5-(Pyrrolidin-2-yl)thiophene-2-carboxylic acid hydrochloride (if enantiomerically pure); Thiophene-2-carboxylic acid, 5-(2-pyrrolidinyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Pyrrolidin-2-Ylthiophene-2-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for advanced research and cGMP-grade production. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, chiral purity (if applicable), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.