Description

tert-Butyl 3-Iodo-6-Methoxy-1H-Indole-1-Carboxylate is a high-value, multi-functional indole derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the strategic placement of reactive iodine and a protected carboxylate group, enabling precise molecular construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of complex heterocyclic compounds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel indole-based drug candidates, including kinase inhibitors and serotonin receptor modulators.
• Agrochemical Research: Used in the development of new herbicides and plant growth regulators that leverage the indole scaffold.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of specialized polymers and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom at the 3-position makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings for carbon-carbon bond formation.
• Medicinal Chemistry SAR Studies: Utilized to explore structure-activity relationships by introducing diverse substituents at the reactive halogen site.
• Chemical Biology Probes: Acts as a starting point for synthesizing fluorescent or affinity-labeled probes to study biological pathways.

Basic Information

Product Name	tert-Butyl 3-Iodo-6-Methoxy-1H-Indole-1-Carboxylate
CAS No.	1268167-84-5
Molecular Formula	C14H16INO3
Molecular Weight	373.19 g/mol
Synonyms	1-Boc-3-iodo-6-methoxyindole; tert-Butyl 3-iodo-6-methoxy-1H-indole-1-carboxylate; 3-Iodo-6-methoxy-1H-indole-1-carboxylic acid tert-butyl ester; 1H-Indole-1-carboxylic acid, 3-iodo-6-methoxy-, 1,1-dimethylethyl ester; Boc-3-I-6-MeO-indole; 3-Iodo-6-methoxyindole-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Iodo-6-Methoxy-1H-Indole-1-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials. Due to its light-sensitive nature, handling should be performed under subdued lighting or using amber glass containers.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.