Description

[2H3]-Quinidine is a stable isotope-labeled analog of the antiarrhythmic alkaloid quinidine, specifically deuterated at three hydrogen positions. This high-purity reference standard is essential for ensuring accuracy and reliability in quantitative analytical methods, particularly in pharmaceutical research and development. It is primarily used by analytical chemists and researchers in pharmaceutical, clinical, and forensic laboratories for applications requiring precise internal standards.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical, non-interfering reference for the accurate quantification of quinidine and its metabolites in complex biological matrices via LC-MS/MS and GC-MS.
• Pharmacokinetic and Metabolic Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Drug Impurity Profiling and Stability Testing: Assists in identifying and quantifying degradation products or process-related impurities in drug substances and products.
• Forensic and Clinical Toxicology: Facilitates the accurate determination of quinidine levels in plasma, serum, or urine for therapeutic drug monitoring or overdose cases.
• Isotope Dilution Analysis: Provides a definitive method for achieving high accuracy and minimizing matrix effects in quantitative analysis.

Basic Information

Product Name	[2H3]-Quinidine
CAS No.	1267657-68-0
Molecular Formula	C20H21D3N2O2
Molecular Weight	327.43 g/mol
Synonyms	Quinidine-d3; Deuterated Quinidine; (9S)-6'-Methoxycinchonan-9-ol-d3; Cinchonan-9-ol, 6'-methoxy-, (9S)-, deuterated; Quinidine (methyl-d3); 2H3-Quinidine
EINECS	Contact for details

Quality Control

Every batch of [2H3]-Quinidine is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, MS, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and solvent content. Our quality commitment ensures the material is suitable for the most demanding GMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.