Description

(2Z)-2-Butenedioic Acid 1-Methyl Ester-D3 is a deuterium-labeled derivative of maleic acid monomethyl ester, serving as a critical stable isotope-labeled internal standard. This high-purity compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry analyses. It is primarily required by researchers and quality control laboratories in the pharmaceutical, agrochemical, and analytical chemistry sectors for method development and validation.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of maleic acid monomethyl ester and related compounds in complex biological and environmental matrices.
• Pharmaceutical Research: Facilitates pharmacokinetic (PK) and metabolism studies of drug candidates and their metabolites in drug discovery and development.
• Analytical Method Development: Enables the development and validation of highly sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Metabolomics and Biomarker Discovery: Supports accurate profiling of organic acids and related metabolic pathways in clinical and life science research.
• Quality Control & Impurity Profiling: Assists in the identification and quantification of process-related impurities in active pharmaceutical ingredient (API) manufacturing.
• Environmental Analysis: Applied in trace-level detection and monitoring of specific chemical analytes in environmental samples.

Basic Information

Product Name	(2Z)-2-Butenedioic Acid 1-Methyl Ester-D3
CAS No.	1266402-66-7
Molecular Formula	C5H3D3O4
Molecular Weight	133.11 g/mol
Synonyms	Maleic Acid Monomethyl Ester-d3; (Z)-2-Butenedioic Acid Monomethyl Ester-d3; Methyl Hydrogen Maleate-d3; Methyl (Z)-2-butenedioate-d3; Monomethyl Maleate-d3; 1-Methyl (2Z)-2-butenedioate-d3; Maleic Acid 1-Methyl Ester-d3; Deuterated Methyl Hydrogen Maleate
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management systems to ensure high isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. Certificates of Analysis (COA) detailing isotopic enrichment (e.g., D3 ≥ 99 atom % D), chemical purity, and analytical data are provided to support your research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 99 atom % D (D3)
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.