Description

Selexipag-D7 is a deuterated isotopologue of the selective prostacyclin receptor agonist Selexipag, specifically labeled with seven deuterium atoms. This compound is a critical internal standard for the precise quantification and pharmacokinetic analysis of Selexipag in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is an essential tool for pharmaceutical research and development, clinical studies, and bioanalytical laboratories focused on pulmonary arterial hypertension (PAH) therapeutics.

Application

• Primary use as a stable isotope-labeled internal standard for the accurate quantification of Selexipag in bioanalytical methods.
• Essential for pharmacokinetic (PK) and metabolism studies during drug development and clinical trials for PAH treatments.
• Enables high-precision LC-MS/MS method development and validation in compliance with regulatory guidelines (FDA, EMA).
• Used in drug metabolism and disposition (DMPK) research to understand the absorption, distribution, metabolism, and excretion of Selexipag.
• Supports quality control and assurance in pharmaceutical manufacturing where trace analysis of the active pharmaceutical ingredient is required.
• Facilitates forensic and anti-doping analysis for the detection and confirmation of Selexipag.

Basic Information

Product Name	Selexipag-D7
CAS No.	1265295-21-3
Molecular Formula	C26H20D7N3O4S
Molecular Weight	~ 470.6 g/mol
Synonyms	Selexipag-d7; 2-{4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy}-N-(methylsulfonyl)acetamide-d7; ACT-293987-d7; Uptravi-d7; NS-304-d7; 2-[4-[(5,6-Diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy]-N-(methylsulfonyl)acetamide-d7; Deuterated Selexipag (7 deuterium atoms)
EINECS	Contact for details

Quality Control

Our Selexipag-D7 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and LC-MS, to confirm identity, isotopic enrichment (≥98 atom % D), and chemical purity (typically ≥95%). A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storage under an inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Isotopic Purity (Atom % D)	≥ 98%
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.