Description

n-(Methylsulfonyl)-2-(1,1,2,2,3,3,4,4-D8-4-((5,6-Diphenylpyrazin-2-Yl)(Isopropyl)Amino)Butoxy)Acetamide is a deuterated, high-purity chemical building block designed for advanced research and development. This compound matters for its role as a stable isotope-labeled intermediate, enabling precise pharmacokinetic and metabolic studies in pharmaceutical discovery. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and biotechnology industries working on novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical deuterated building block in the synthesis of novel active pharmaceutical ingredients (APIs).
• Metabolic Tracing: Used in the development of deuterium-labeled drug candidates for advanced ADME (Absorption, Distribution, Metabolism, and Excretion) studies.
• Isotope Labeling: Enables the incorporation of stable deuterium atoms into target molecules to study reaction mechanisms and metabolic pathways.
• Preclinical Research: Supports drug discovery programs focused on oncology, CNS disorders, and other therapeutic areas requiring labeled compounds.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and validation in bioanalytical laboratories.
• Chemical Biology Probes: Acts as a precursor for creating labeled probes to investigate biological targets and protein interactions.

Basic Information

Product Name	n-(Methylsulfonyl)-2-(1,1,2,2,3,3,4,4-D8-4-((5,6-Diphenylpyrazin-2-Yl)(Isopropyl)Amino)Butoxy)Acetamide
CAS No.	1265295-16-6
Molecular Formula	C26H26D8N4O4S
Molecular Weight	~506.67 g/mol
Synonyms	1265295-16-6; Deuterated N-(Methylsulfonyl)-2-[4-[[5,6-diphenylpyrazin-2-yl](propan-2-yl)amino]butoxy]acetamide; D8-Labeled Acetamide Derivative; 2-[4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide-d8; (1,1,2,2,3,3,4,4-Octadeutero)-4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butyl 2-(methylsulfonamido)acetate (tautomer); Deuterated Pyrazine Acetamide; Isopropyl-diphenylpyrazinylbutoxy Acetamide Sulfonamide-d8
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of n-(Methylsulfonyl)-2-(1,1,2,2,3,3,4,4-D8-4-((5,6-Diphenylpyrazin-2-Yl)(Isopropyl)Amino)Butoxy)Acetamide is characterized and verified for identity, purity, and isotopic enrichment. Certificates of Analysis (COA) detailing specific batch results, including HPLC purity, NMR confirmation, and deuterium incorporation, are available upon request. We adhere to cGMP principles for advanced pharmaceutical intermediates to ensure supply reliability and data integrity for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to maintain stability and prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Deuterium Incorporation (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.