Description

1-Methyl-5-(Trifluoromethyl)-1H-Indole is a high-value, multi-functional indole derivative distinguished by its trifluoromethyl substituent. This compound is a critical synthetic intermediate prized for its ability to impart desirable physicochemical properties, such as enhanced metabolic stability and lipophilicity, into target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of next-generation pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Material Science Research: Serves as a precursor for advanced organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient aromatic system.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create specialized ligands for catalysis, enabling more efficient and selective synthetic transformations.
• Fluorine Chemistry Studies: An important substrate for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in heterocyclic compounds.

Basic Information

Item	Details
Product Name	1-Methyl-5-(Trifluoromethyl)-1H-Indole
CAS No.	1264670-41-8
Molecular Formula	C10H8F3N
Molecular Weight	199.17 g/mol
Synonyms	5-(Trifluoromethyl)-1-methylindole; 1-Methyl-5-trifluoromethylindole; 1-Methyl-5-(trifluoromethyl)indole; 5-(Trifluoromethyl)-1-methyl-1H-indole; 1H-Indole, 1-methyl-5-(trifluoromethyl)-; 1-Methyl-5-(trifluoromethyl)indole; 1-Methyl-5-(trifluoromethyl)-1H-indole
EINECS	Contact for details

Quality Control

Our 1-Methyl-5-(Trifluoromethyl)-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.