Description

5,6,7,8-Tetrahydro-Isoquinolin-5-Ylamine Dihydrochloride is a high-purity, pharmaceutically relevant organic salt, serving as a critical building block in advanced chemical synthesis. Its primary value lies in its role as a versatile amine intermediate for the development of novel active pharmaceutical ingredients (APIs) and complex organic molecules. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries, particularly those focused on medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting neurological and cardiovascular pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and library synthesis.
• Agrochemical Development: Serves as an intermediate in the creation of new pesticides and herbicides.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex, high-value specialty chemicals.
• Bioconjugation & Probe Development: The amine functionality allows for conjugation to biomolecules or fluorescent tags for diagnostic applications.
• Catalyst & Ligand Preparation: Used in the preparation of chiral ligands or organocatalysts for asymmetric synthesis.

Basic Information

Product Name	5,6,7,8-Tetrahydro-Isoquinolin-5-Ylamine Dihydrochloride
CAS No.	1263378-92-2
Molecular Formula	C9H14N2·2HCl
Molecular Weight	231.14 g/mol
Synonyms	5-Amino-5,6,7,8-tetrahydroisoquinoline dihydrochloride; 5,6,7,8-Tetrahydroisoquinolin-5-amine dihydrochloride; 5-Aminotetrahydroisoquinoline dihydrochloride; 5,6,7,8-Tetrahydro-5-isoquinolinamine dihydrochloride; THIQ-5-Amine 2HCl; 1,2,3,4-Tetrahydroisoquinolin-5-amine dihydrochloride
EINECS	Contact for details

Quality Control

Our 5,6,7,8-Tetrahydro-Isoquinolin-5-Ylamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.