Description

6-Methoxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid Hydrochloride is a high-purity, synthetically derived chemical building block of significant importance in advanced organic synthesis. Its value lies in its role as a key chiral intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral scaffold in the research and synthesis of potential new drug candidates, particularly for central nervous system (CNS) targets.
• Agrochemical Synthesis: Used as a building block for developing novel, high-efficacy crop protection agents and herbicides.
• Fine Chemical Production: Employed in the manufacture of complex, high-value specialty chemicals requiring specific stereochemistry.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting studies in medicinal chemistry and synthetic methodology.
• Process Chemistry Development: Utilized for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Ligand and Catalyst Preparation: Acts as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	6-Methoxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid Hydrochloride
CAS No.	1263377-98-5
Molecular Formula	C12H15NO3·HCl
Molecular Weight	257.71 g/mol
Synonyms	1-Carboxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride; (1S)-6-Methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid hydrochloride (if applicable); 6-Methoxy-THIQ-1-COOH·HCl; 6-MeO-THIQ-1-Carboxylic Acid HCl; 6-Methoxy-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid hydrochloride; L-6-Methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid hydrochloride; (S)-6-Methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 6-Methoxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.