Description

1-(Bromomethyl)-3-(Difluoromethyl)Benzene, also known as 3-(Bromomethyl)-Alpha,α-Difluorotoluene or 3-(Bromomethyl)Benzal Fluoride, is a versatile aromatic building block featuring both bromomethyl and difluoromethyl functional groups. This compound is valued for its dual reactivity, enabling sequential functionalization and serving as a key intermediate in the synthesis of complex molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring difluoromethyl or benzyl bromide motifs for further coupling reactions.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the creation of fluorinated polymers, liquid crystals, and organic electronic materials to modify physical and chemical properties.
• Chemical Biology Probes: Useful for the site-specific labeling of biomolecules or the synthesis of fluorinated analogs for metabolic and mechanistic studies.

Basic Information

Product Name	1-(Bromomethyl)-3-(Difluoromethyl)Benzene
CAS No.	1263178-51-3
Molecular Formula	C9H7BrF2
Molecular Weight	233.05 g/mol
Synonyms	3-(Bromomethyl)-Alpha,α-Difluorotoluene; 3-(Bromomethyl)Benzal Fluoride; 3-(Bromomethyl)-α,α-Difluorotoluene; 1-(Bromomethyl)-3-(Difluoromethyl)Benzene; 3-(Bromomethyl)benzylidene Difluoride; (3-(Bromomethyl)phenyl)difluoromethane; m-(Bromomethyl)benzal Fluoride
EINECS	Contact for details

Quality Control

Our 1-(Bromomethyl)-3-(Difluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.