Description

3-(Difluoromethoxy)Isoquinoline is a specialized heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the difluoromethoxy-substituted isoquinoline scaffold, enabling the development of novel compounds with enhanced metabolic stability and bioavailability. This high-purity intermediate is primarily sought by research and development teams within the pharmaceutical and agrochemical industries for the creation of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Research: Serves as a versatile building block for synthesizing novel herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve lipophilicity and biological activity.
• Ligand & Catalyst Development: Utilized in the design and synthesis of novel ligands for catalysis and metal-organic frameworks (MOFs) due to its nitrogen-containing heterocyclic structure.
• Material Science Precursor: Employed in the development of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Fluorine Chemistry Studies: Acts as a valuable substrate for investigating new fluorination methodologies and studying the effects of fluorine atoms on molecular properties.

Basic Information

Product Name	3-(Difluoromethoxy)Isoquinoline
CAS No.	1261770-41-5
Molecular Formula	C10H7F2NO
Molecular Weight	195.17 g/mol
Synonyms	Isoquinoline, 3-(difluoromethoxy)-; 3-(Difluoromethoxy)isoquinoline; 1261770-41-5; 3-Difluoromethoxyisoquinoline; 3-(Difluoromethoxy)-isoquinoline; 3-(Difluoromethoxy)isoquinoline (CAS 1261770-41-5); 3-(Difluoromethoxy)isoquinoline, 95+%
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Isoquinoline is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to support cGMP and ISO standards for reliable, batch-to-batch consistency critical for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.