Description

1-(Difluoromethoxy)Isoquinoline is a specialized fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the difluoromethoxy substituent, which is a key motif for modulating the biological activity and metabolic stability of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance lipophilicity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes and tags for studying biological systems and enzyme mechanisms.
• Fluorine Chemistry Research: An important substrate for studying novel fluorination reactions and the effects of fluorine substitution on aromatic systems.

Basic Information

Product Name	1-(Difluoromethoxy)Isoquinoline
CAS No.	1261636-30-9
Molecular Formula	C₁₀H₇F₂NO
Molecular Weight	195.17 g/mol
Synonyms	Isoquinoline, 1-(difluoromethoxy)-; 1-(Difluoromethoxy)isoquinoline; 1-(Difluoromethoxy)-isoquinoline; Difluoromethoxy-isoquinoline; 1261636-30-9; 1-(Difluoromethoxy)isoquinoline; 1-(Difluoromethoxy)isoquinoline (CAS 1261636-30-9)
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethoxy)Isoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process development. A detailed Certificate of Analysis (COA) providing purity (typically by HPLC or GC), identity confirmation (by IR, NMR, or MS), and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.