Description

2-Chloro-4,5-Difluoroiodobenzene is a high-purity, multi-halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring chlorine, fluorine, and iodine substituents, makes it a versatile intermediate for constructing complex molecules with precise electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoro and iodo groups contribute to biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine moiety acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Heck) to form biaryl and other conjugated systems.
• Fluorination & Functionalization Studies: Used as a model substrate in methodological development for selective halogen exchange (e.g., F/Cl exchange) or further functional group transformations.
• Ligand & Catalyst Development: Employed in the preparation of sophisticated ligands for catalysis or as a core structure in catalyst design.

Basic Information

Product Name	2-Chloro-4,5-Difluoroiodobenzene
CAS No.	1261629-20-2
Molecular Formula	C6H2ClF2I
Molecular Weight	274.44 g/mol
Synonyms	1-Chloro-2,3-difluoro-4-iodobenzene; 2,3-Difluoro-4-iodochlorobenzene; Benzene, 2-chloro-1,4-difluoro-3-iodo-; 4-Iodo-2,3-difluorochlorobenzene; 2-Chloro-1,4-difluoro-3-iodobenzene; 3-Iodo-4,5-difluorochlorobenzene; 2-Chloro-4,5-difluoro-1-iodobenzene
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4,5-Difluoroiodobenzene is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) including purity (typically ≥97% by HPLC/NMR), identity confirmation, and impurity profile is supplied with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.