Description

4-Chloro-n-(Naphthalen-1-Ylmethyl)-5-(3-(Piperazin-1-Yl)Phenoxy)Thiophene-2-Sulfonamide is a high-purity, advanced pharmaceutical intermediate designed for research and development in medicinal chemistry. This compound is valued for its complex heterocyclic structure, which serves as a critical building block in the synthesis of novel therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new drug candidates, particularly in areas requiring sophisticated sulfonamide and piperazine-based scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential new chemical entities (NCEs) for drug discovery programs.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies, particularly for targets involving sulfonamide pharmacophores.
• Biochemical Tool Compound: Serves as a research-grade standard or inhibitor in biochemical assays to study specific enzyme or receptor interactions.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to construct more complex molecules for academic and industrial research.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.

Basic Information

Product Name	4-Chloro-n-(Naphthalen-1-Ylmethyl)-5-(3-(Piperazin-1-Yl)Phenoxy)Thiophene-2-Sulfonamide
CAS No.	1261576-81-1
Molecular Formula	C25H24ClN3O3S2
Molecular Weight	514.06 g/mol
Synonyms	4-Chloro-N-[(naphthalen-1-yl)methyl]-5-[3-(piperazin-1-yl)phenoxy]thiophene-2-sulfonamide; 4-Chloro-5-(3-piperazin-1-yl-phenoxy)-N-(naphthalen-1-ylmethyl)thiophene-2-sulfonamide; 1-[3-[[5-[(1-Naphthylmethyl)sulfamoyl]-4-chloro-2-thienyl]oxy]phenyl]piperazine; 1261576-81-1; Thiophene-2-sulfonamide derivative; N-(1-Naphthylmethyl)sulfonamide intermediate
EINECS	Contact for details

Quality Control

Our 4-Chloro-n-(Naphthalen-1-Ylmethyl)-5-(3-(Piperazin-1-Yl)Phenoxy)Thiophene-2-Sulfonamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable for pharmaceutical intermediates, ensuring traceability and documentation for regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.