Description

2-(Bromomethyl)-1-Iodo-3-Methylbenzene, also known as α-Bromo-6-Iodo-o-Xylene, is a high-value, multi-functional halogenated aromatic building block. Its unique structure, featuring both bromomethyl and iodo substituents on a methylbenzene core, makes it a versatile intermediate for introducing specific molecular complexity. This compound is essential for researchers and manufacturers in advanced organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and functional materials. The presence of two distinct halogen handles allows for sequential, site-selective cross-coupling and functionalization reactions.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for constructing complex aromatic scaffolds and for use in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where specific halogenated aromatic motifs are required for bioactivity.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing specialized phosphine or N-heterocyclic carbene (NHC) ligands used in homogeneous catalysis.
• Material Science Research: Employed in the creation of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, by serving as a halogenated building block for polymerization or small-molecule synthesis.
• Chemical Biology & Proteomics: Useful for synthesizing molecular probes, affinity labels, or linker molecules for studying biological systems due to its reactive halogen sites.
• Custom Synthesis & Contract Manufacturing: A critical reagent for fine chemical and custom synthesis houses serving the global R&D and scale-up markets.

Basic Information

Product Name	2-(Bromomethyl)-1-Iodo-3-Methylbenzene, α-Bromo-6-Iodo-o-Xylene
CAS No.	1261481-48-4
Molecular Formula	C9H10BrI
Molecular Weight	325.99 g/mol
Synonyms	1-Bromomethyl-2-iodo-3-methylbenzene; 2-Bromomethyl-1-iodo-3-methylbenzene; 6-Iodo-2-methylbenzyl bromide; α-Bromo-6-iodo-o-xylene; o-Xylene, α-bromo-6-iodo-; (2-Iodo-6-methylphenyl)methyl bromide; 1-Iodo-2-(bromomethyl)-3-methylbenzene
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our halogenated aromatic intermediates. Every batch of 2-(Bromomethyl)-1-Iodo-3-Methylbenzene is analyzed using advanced techniques including GC, HPLC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. Our quality system is designed to meet the exacting standards of pharmaceutical and advanced synthetic chemistry applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (GC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.