Description

1,4-Butanediol-D8 Mononitrate is a deuterated isotopologue of 1,4-butanediol mononitrate, where eight hydrogen atoms are replaced with deuterium, a stable hydrogen isotope. This high-purity labeled compound is essential for advanced analytical and research applications where precise molecular tracking and quantification are required. It is primarily utilized by researchers and scientists in the fields of pharmaceutical development, metabolic studies, and analytical chemistry as an internal standard for mass spectrometry.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical reference compound in quantitative LC-MS and GC-MS analysis for accurate measurement of its non-deuterated counterpart or related metabolites.
• Pharmaceutical Research & Drug Metabolism: Used in pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies to trace and quantify drug compounds and their pathways.
• Biochemical Research: Employed in mechanistic studies to investigate nitrated compound pathways and biochemical transformations using deuterium as a stable isotopic label.
• Analytical Method Development: Essential for developing and validating highly sensitive and specific analytical methods in regulatory and quality control environments.
• Forensic and Doping Control Analysis: Provides a reliable standard for the precise identification and quantification of substances in complex biological matrices.

Basic Information

Product Name	1,4-Butanediol-D8 Mononitrate
CAS No.	1261398-94-0
Molecular Formula	C4D8NO3
Molecular Weight	152.18 g/mol (approx.)
Synonyms	1,4-Butanediol-d8 1-Nitrate; Tetramethylene-d8 Glycol Mononitrate; Butane-1,4-diol-d8 Mononitrate; Deuterated 1,4-Butanediol Mononitrate; [2H8]-1,4-Butanediol Mononitrate; BDO-d8 Mononitrate; 1-Nitrooxy-1,4-butanediol-d8
EINECS	Contact for details

Quality Control

Every batch of 1,4-Butanediol-D8 Mononitrate is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical documentation. A detailed Certificate of Analysis (COA) is provided with each shipment, reporting key parameters such as isotopic enrichment (Atom % D), chemical purity by HPLC/GC, and identity confirmation by NMR and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.