Description

Nortramadol-D3 Hydrochloride is a high-purity, deuterium-labeled internal standard essential for precise analytical quantification. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in sensitive mass spectrometry-based analyses. It is primarily utilized by pharmaceutical R&D laboratories, forensic toxicology units, and contract research organizations (CROs) for method development, validation, and routine drug metabolism and pharmacokinetics (DMPK) studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the quantitative analysis of tramadol and its metabolites in biological matrices.
• Pharmaceutical Research & Development: Used in method development and validation for drug metabolism and pharmacokinetic (DMPK) studies.
• Forensic Toxicology: Enables accurate quantification in post-mortem and human performance testing for tramadol-related cases.
• Clinical Trial Analysis: Supports bioanalytical assays for monitoring drug and metabolite levels in plasma, serum, and urine during clinical studies.
• Metabolite Identification Studies: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex samples.
• Quality Control in Reference Material Production: Used as a calibrant in the production and certification of certified reference materials (CRMs).

Basic Information

Product Name	Nortramadol-D3 Hydrochloride
CAS No.	1261398-09-7
Molecular Formula	C₁₆H₂₂D₃NO₂•HCl
Molecular Weight	299.85 g/mol (approx.)
Synonyms	O-Desmethyltramadol-D3 Hydrochloride; N-Desmethyltramadol-D3 HCl; Nortramadol D3 HCl; [2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol-D3] Hydrochloride; Tramadol Metabolite M1-D3 Hydrochloride; Nor-Tramadol-D3 HCl; 1-(3-Methoxyphenyl)-2-[(dimethyl-d3-amino)methyl]cyclohexan-1-ol Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Nortramadol-D3 Hydrochloride is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical documentation, including a detailed Certificate of Analysis (COA) that confirms identity, chemical purity, isotopic purity (enrichment), and chromatographic profile. Our quality commitment ensures the material meets the stringent requirements for use as an internal standard in regulated bioanalytical environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Enrichment)	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.