Description

Imipenem-D4 is a deuterated isotopologue of the broad-spectrum carbapenem antibiotic Imipenem, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is an essential internal standard for the precise and accurate quantification of Imipenem in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for pharmaceutical research and development, clinical pharmacology, and bioanalytical laboratories requiring the highest level of accuracy in pharmacokinetic and metabolic studies.

Application

• Bioanalytical Reference Standard: Serves as a primary internal standard for the quantitative analysis of Imipenem in plasma, serum, urine, and tissue homogenates via mass spectrometry.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise measurement of drug concentration-time profiles to determine absorption, distribution, metabolism, and excretion (ADME) parameters.
• Clinical Trial Support: Used in regulated bioanalysis to ensure data integrity and meet FDA/EMA guidelines for method validation in clinical studies.
• Metabolite Identification & Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex mass spectra.
• Method Development & Validation: Critical for establishing robust, sensitive, and specific LC-MS/MS methods in quality control and research laboratories.
• Doping Control & Forensic Analysis: Supports accurate detection and confirmation of Imipenem misuse in sports or forensic investigations.

Basic Information

Product Name	Imipenem-D4
CAS No.	1261396-26-2
Molecular Formula	C12H15D4N3O4S
Molecular Weight	317.38 g/mol (for monohydrate form)
Synonyms	(5R,6S)-3-[[2-(Deuteriomethylthio)ethyl]thio]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid-D4; (5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-[[2-[(methyl-d3)thio]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic-2-d acid; Imipenem-d4; N-Formimidoylthienamycin-D4; MK-0787-D4; Imipenem (deuterated, 4X)
EINECS	Contact for details

Quality Control

Every batch of Imipenem-D4 is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to ensure identity, purity, and isotopic enrichment meet the exacting standards required for quantitative mass spectrometry. A detailed Certificate of Analysis (COA) is supplied with each product, reporting key parameters including HPLC purity, isotopic purity (D-enrichment), water content, and residual solvents. Our quality commitment supports compliance with GLP and GMP principles for research and regulated studies.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture absorption. The product is stable under these conditions for extended periods.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.