Description

Piperaquine-D6 is a deuterated internal standard of the antimalarial drug piperaquine, specifically designed for use in quantitative analytical methods. This high-purity compound is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical researchers, clinical laboratories, and contract research organizations (CROs) engaged in drug development and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled reference compound for the precise quantification of piperaquine in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of piperaquine.
• Bioanalytical Method Development & Validation: Critical for developing and validating robust, sensitive, and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Therapeutic Drug Monitoring (TDM): Enables accurate measurement of piperaquine concentrations in patient samples to optimize dosing regimens and ensure therapeutic efficacy.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development for piperaquine-containing drug formulations.
• Clinical Research: Facilitates reliable data generation in clinical trials investigating antimalarial drug combinations and efficacy.

Basic Information

Item	Detail
Product Name	Piperaquine-D6
CAS No.	1261394-71-1
Molecular Formula	C29H26D6Cl2N6
Molecular Weight	535.56 g/mol
Synonyms	1,3-Bis[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propane-d6; Piperaquine-d6; 1,3-Bis(4-(7-chloro-4-quinolyl)-1-piperazinyl)propane-d6; Deuterated Piperaquine; Piperaquine (hexadeuterated); 1,3-Bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)propane-d6; Internal Standard Piperaquine-d6
EINECS	Contact for details

Quality Control

Our Piperaquine-D6 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic purity (by MS), and related substances. We support research and development that demands reliable and traceable reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.