Description

[2H10]-Amiodarone Hydrochloride CAS NO 1261393-77-4 is a deuterium-labeled analog of the potent class III antiarrhythmic agent, amiodarone. This stable isotope-labeled compound is an essential internal standard for the precise quantification of amiodarone and its metabolites in complex biological matrices using advanced analytical techniques. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Bioanalytical Internal Standard: Serves as a critical reference compound for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis in drug metabolism and pharmacokinetics (DMPK) studies.
• Pharmacokinetic Research: Enables accurate tracking and quantification of amiodarone absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Metabolite Identification: Aids in the structural elucidation and quantification of amiodarone metabolites using isotope pattern recognition in mass spectrometry.
• Therapeutic Drug Monitoring (TDM) Assay Development: Used to develop and validate highly sensitive and specific clinical assays for monitoring amiodarone plasma concentrations in patients.
• Quality Control in Pharmaceutical Manufacturing: Can be employed as a reference standard in the quality control of amiodarone hydrochloride active pharmaceutical ingredient (API) and finished dosage forms.
• Forensic and Toxicology Analysis: Provides a reliable standard for the confirmatory analysis of amiodarone in forensic and clinical toxicology investigations.

Basic Information

Product Name	[2H10]-Amiodarone Hydrochloride
CAS No.	1261393-77-4
Molecular Formula	C25H19D10ClI2NO3 • HCl
Molecular Weight	695.69 g/mol (for monoisotopic mass)
Synonyms	Deuterated Amiodarone Hydrochloride; Amiodarone-d10 Hydrochloride; 2-Butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone-d10 hydrochloride; (2-Butyl-3-benzofuranyl)[4-[2-(diethyl-d10-amino)ethoxy]-3,5-diiodophenyl]methanone hydrochloride; Cordarone-d10 Hydrochloride; Atlansil-d10 Hydrochloride
EINECS	Contact for details

Quality Control

Our [2H10]-Amiodarone Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment, chemical purity, and identity confirmation. We adhere to relevant industry standards for reference materials to ensure reliable and reproducible performance in your LC-MS/MS workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.