Description

Propofol-D17 is a stable isotope-labeled analog of the widely used intravenous anesthetic agent, propofol. This deuterated compound is an essential internal standard for the precise and accurate quantification of propofol in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units engaged in pharmacokinetic studies, therapeutic drug monitoring, and bioanalytical method development and validation.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the LC-MS/MS quantification of propofol in plasma, serum, and tissue homogenates.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Research: Enables accurate tracking of drug concentration over time in preclinical and clinical studies.
• Forensic and Clinical Toxicology: Used in assays to determine propofol levels in post-mortem investigations or cases of suspected overdose.
• Drug Metabolism and Disposition Studies: Aids in elucidating the metabolic pathways and clearance mechanisms of propofol.
• Method Development and Validation: Essential for developing robust, selective, and sensitive analytical methods compliant with FDA, EMA, and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Can be employed in impurity profiling and assay validation of propofol-based formulations.

Basic Information

Product Name	Propofol-D17
CAS No.	1261393-54-7
Molecular Formula	C12H11D17O
Molecular Weight	187.36 g/mol (approx.)
Synonyms	2,6-Diisopropylphenol-D17; 2,6-Bis(1-methylethyl)phenol-D17; Diprivan-D17; Propofol (phenyl-D5, isopropyl-D6); Deuterated Propofol; Propofol-d17; [2H17]-Propofol
EINECS	Contact for details

Quality Control

Our Propofol-D17 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive mass spectrometry applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC/NMR), isotopic purity (by MS), and residual solvents. We support research compliance with standards relevant to analytical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the product label or CoA. Keep the container in a dry, well-ventilated place.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.