Description

Candesartan Cilexetil-D11 is a deuterated analog of the angiotensin II receptor blocker (ARB) candesartan cilexetil, specifically labeled with eleven deuterium atoms. This stable isotope-labeled compound is a critical reference standard and internal standard for ensuring the accuracy and reliability of quantitative bioanalytical methods. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and clinical trial sample analysis for candesartan.

Application

• Bioanalytical Reference Standard: Serves as a primary standard for the calibration and validation of LC-MS/MS and GC-MS methods used in drug development.
• Mass Spectrometry Internal Standard: Used as a stable isotope-labeled internal standard to correct for matrix effects and instrument variability in the quantitative analysis of candesartan in biological matrices (plasma, serum, urine).
• Pharmacokinetic and Metabolism Studies: Essential for conducting accurate Absorption, Distribution, Metabolism, and Excretion (ADME) studies and bioavailability/bioequivalence testing.
• Clinical Research: Supports the analysis of patient samples in clinical trials to monitor drug concentration levels.
• Impurity Profiling and Characterization: Aids in the identification and quantification of metabolites and related substances.
• Regulatory Compliance: Provides traceable standards necessary for submissions to regulatory bodies like the FDA and EMA.

Basic Information

Product Name	Candesartan Cilexetil-D11
CAS No.	1261393-19-4
Molecular Formula	C33H23D11N6O6
Molecular Weight	625.71 g/mol (approximate)
Synonyms	(±)-1-Hydroxyethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate-D11; 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid 1-(cyclohexyloxycarbonyloxy)ethyl ester-D11; TCV-116-D11; CV-11974-D11 cilexetil ester; BLOPRESS-D11; ATACAND-D11; Deuterated Candesartan Cilexetil
EINECS	Contact for details

Quality Control

Our Candesartan Cilexetil-D11 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical identity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (D11), chemical purity, and analytical results. We adhere to relevant industry guidelines to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D11)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.