Description

4-Iodo-5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine CAS NO 1261365-97-2 is a high-value, halogenated heterocyclic building block designed for advanced organic synthesis. This compound is critical for medicinal chemistry research and development, particularly in the creation of novel small-molecule therapeutics. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in drug discovery programs targeting a range of diseases.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization due to its unique iodine and trifluoromethyl substituents.
• Agrochemical Development: Employed in the research and synthesis of novel crop protection agents and pesticides.
• Material Science: A potential building block for advanced organic electronic materials and functional polymers.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex molecular architectures.
• Chemical Biology Probes: Used in the development of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	4-Iodo-5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1261365-97-2
Molecular Formula	C8H4F3IN2
Molecular Weight	312.03 g/mol
Synonyms	4-Iodo-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-iodo-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-4-iodo-1H-pyrrolo[2,3-b]pyridine; 4-Iodo-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine; 1261365-97-2; CF3-substituted pyrrolopyridine iodide; Iodo-trifluoromethyl pyrrolopyridine
EINECS	Contact for details

Quality Control

Our 4-Iodo-5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.