Description

(R)-3-(5-Bromo-Thiophene-2-Sulfonylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial importance. Its value lies in its role as a key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting G-protein-coupled receptors (GPCRs) or enzymes where the pyrrolidine sulfonamide scaffold is pharmacologically relevant.
• Protease Inhibitor Research: Used in the development of inhibitors for various proteases, leveraging the sulfonamide group as a key pharmacophore for binding to active sites.
• Agrochemical Synthesis: Serves as a precursor in the creation of advanced, stereospecific agrochemicals where the bromo-thiophene moiety can be further functionalized.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis or as a scaffold for metal-organic frameworks (MOFs) in material science.
• Chemical Biology Probes: Utilized to create activity-based probes or labeled compounds for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	(R)-3-(5-Bromo-Thiophene-2-Sulfonylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1261235-40-8
Molecular Formula	C13H19BrN2O4S2
Molecular Weight	435.34 g/mol
Synonyms	tert-Butyl (3R)-3-[[(5-bromothiophen-2-yl)sulfonyl]amino]pyrrolidine-1-carboxylate; (R)-1-Boc-3-((5-bromothiophene-2-sulfonamido)pyrrolidine; (3R)-3-({[5-Bromo-2-thienyl]sulfonyl}amino)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester; (R)-N-((5-Bromothiophen-2-yl)sulfonyl)-1-Boc-pyrrolidin-3-amine; 1-Boc-3-((5-bromothiophene-2-sulfonamido)-(R)-pyrrolidine; Boc-Pyrrolidine-(R)-3-yl-(5-bromo-thiophene-2-sulfonyl)-amine
EINECS	Contact for details

Quality Control

Our (R)-3-(5-Bromo-Thiophene-2-Sulfonylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.