Description

2-(1H-1,3-Benzodiazol-2-Yl)-3-(4-Chlorophenyl)Propanethioamide is a high-purity, non-nucleoside benzimidazole derivative with a thioamide functional group, serving as a critical advanced pharmaceutical intermediate. This compound matters for its role in the research and development of novel therapeutic agents, particularly in antiviral and anticancer drug discovery programs. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in synthesizing complex bioactive molecules.

Application

• Key intermediate in the synthesis of novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) for antiviral research.
• Precursor for the development of benzimidazole-based kinase inhibitors targeting various cancer pathways.
• Building block for medicinal chemistry programs exploring protease inhibitors and other enzyme-targeted therapies.
• Research chemical for studying structure-activity relationships (SAR) in heterocyclic compound libraries.
• Starting material for the preparation of fluorescent probes or molecular sensors due to the benzimidazole core.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	2-(1H-1,3-Benzodiazol-2-Yl)-3-(4-Chlorophenyl)Propanethioamide
CAS No.	1260920-39-5
Molecular Formula	C₁₆H₁₄ClN₃S
Molecular Weight	315.82 g/mol
Synonyms	2-(1H-Benzimidazol-2-yl)-3-(4-chlorophenyl)propanethioamide; 3-(4-Chlorophenyl)-2-(1H-benzimidazol-2-yl)propanethioamide; 2-(1H-1,3-Benzodiazol-2-yl)-3-(4-chlorophenyl)propane-1-thioamide; 1260920-39-5; Benzimidazole thioamide derivative; 4-Chlorophenyl benzimidazole propanethioamide
EINECS	Contact for details

Quality Control

Our 2-(1H-1,3-Benzodiazol-2-Yl)-3-(4-Chlorophenyl)Propanethioamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere when not in use to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.