Description

7-Bromo-4-Fluoroindolin-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated indolinone core structure. This compound is of significant value for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of small molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its halogenated, fused-ring system.
• Kinase Inhibitor Development: Serves as a core scaffold for the development of protein kinase inhibitors, a major class of oncology therapeutics.
• Chemical Biology Probes: Utilized in the creation of chemical probes to study biological processes and identify new drug targets.
• Custom Synthesis: Employed by fine chemical manufacturers for the custom synthesis of complex, high-value compounds under cGMP or research-grade conditions.

Basic Information

Product Name	7-Bromo-4-Fluoroindolin-2-One
CAS No.	1260903-29-4
Molecular Formula	C8H5BrFNO
Molecular Weight	230.04 g/mol
Synonyms	7-Bromo-4-fluoro-2,3-dihydro-1H-indol-2-one; 4-Fluoro-7-bromoindolin-2-one; 2H-Indol-2-one, 7-bromo-4-fluoro-1,3-dihydro-; 7-Bromo-4-fluoro-1,3-dihydro-2H-indol-2-one; 1260903-29-4; 4-Fluoro-7-bromo-2-indolinone
EINECS	Contact for details

Quality Control

Our 7-Bromo-4-Fluoroindolin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports applications in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.