Description

tert-Butyl 6-Fluoro-3-(Hydroxymethyl)-1H-Indole-1-Carboxylate is a high-purity, protected indole derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its molecular architecture, featuring a reactive hydroxymethyl group and a fluoro substituent, makes it an indispensable building block for constructing complex heterocyclic compounds. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of small molecule drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, leveraging the biological activity of the fluorinated indole scaffold.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for creating molecular probes and activity-based protein profiling (ABPP) reagents.
• Material Science Research: Serves as a monomer or functional unit in the development of specialty polymers and advanced organic electronic materials.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	tert-Butyl 6-Fluoro-3-(Hydroxymethyl)-1H-Indole-1-Carboxylate
CAS No.	1260801-80-6
Molecular Formula	C14H16FNO3
Molecular Weight	265.28 g/mol
Synonyms	1-Boc-6-Fluoro-3-hydroxymethylindole; 6-Fluoro-3-(hydroxymethyl)-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 6-fluoro-3-(hydroxymethyl)indole-1-carboxylate; 1H-Indole-1-carboxylic acid, 6-fluoro-3-(hydroxymethyl)-, 1,1-dimethylethyl ester; Boc-6-F-3-CH2OH-Indole; 1260801-80-6; 6-Fluoro-1H-indole-3-methanol, 1-Boc derivative
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 6-Fluoro-3-(Hydroxymethyl)-1H-Indole-1-Carboxylate adheres to stringent quality management protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.