Description

3-Azabicyclo[3.1.0]Hexane-6-Carboxylic Acid Hcl is a high-purity, advanced pharmaceutical intermediate featuring a unique strained bicyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting the central nervous system and other therapeutic areas. It is primarily utilized by R&D scientists and process chemists in pharmaceutical, biotechnology, and fine chemical industries seeking to develop new drug candidates with improved efficacy and pharmacokinetic profiles.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in neuroscience and psychiatric disorder research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained, three-dimensional bicyclic structure.
• API Development: Serves as a core scaffold in the development of Active Pharmaceutical Ingredients (APIs) for clinical trials.
• Chemical Biology: Employed as a probe or ligand in the study of biological targets and enzyme inhibition.
• Process Research: Used for scaling up synthetic routes and developing robust, GMP-compliant manufacturing processes.
• Custom Synthesis: Foundation for the custom synthesis of more complex, proprietary molecules for client-specific projects.

Basic Information

Product Name	3-Azabicyclo[3.1.0]Hexane-6-Carboxylic Acid Hcl
CAS No.	1260794-12-4
Molecular Formula	C7H11NO2 • HCl
Molecular Weight	177.63 g/mol (Free base: 141.17 g/mol)
Synonyms	3-Azabicyclo[3.1.0]hexane-6-carboxylic acid hydrochloride; 6-Carboxy-3-azabicyclo[3.1.0]hexane hydrochloride; (1R,5S)-3-Azabicyclo[3.1.0]hexane-6-carboxylic acid HCl; 3-Aza-bicyclo[3.1.0]hexane-6-carboxylic acid HCl salt; Azabicyclohexanecarboxylic acid HCl; Bicyclic proline derivative HCl
EINECS	Contact for details

Quality Control

Our 3-Azabicyclo[3.1.0]Hexane-6-Carboxylic Acid Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Assay (Titration)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.