Description

2,2,2-Trifluoro-1-(5-Fluoro-3-Indolyl)Ethanone is a high-purity fluorinated indole derivative, a crucial building block in advanced organic synthesis. Its value lies in its unique molecular structure, which is essential for introducing specific fluorinated motifs into target molecules, thereby modulating their biological activity and physicochemical properties. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced, high-performance pesticides and herbicides where fluorination enhances stability and efficacy.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials with tailored properties.
• Fluorination Chemistry Studies: An important reagent in academic and industrial laboratories exploring new methodologies in selective fluorination and heterocyclic chemistry.
• Bioconjugation & Probe Development: Utilized in the synthesis of fluorescent probes and biochemical tools for diagnostic and research applications.

Basic Information

Product Name	2,2,2-Trifluoro-1-(5-Fluoro-3-Indolyl)Ethanone
CAS No.	1260793-83-6
Molecular Formula	C10H5F4NO
Molecular Weight	231.15 g/mol
Synonyms	1-(5-Fluoro-1H-indol-3-yl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(5-fluoro-1H-indol-3-yl)ethanone; 5-Fluoro-3-(trifluoroacetyl)indole; 3-Trifluoroacetyl-5-fluoroindole; 5-Fluoro-1H-indole-3-yl trifluoromethyl ketone; 5-Fluoro-3-indolyl trifluoromethyl ketone; TFI-Ketone (abbrev.); 1260793-83-6
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(5-Fluoro-3-Indolyl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.