Description

7-Bromo-4-(Trifluoromethyl)-1H-Indole is a high-value halogenated indole derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and trifluoromethyl substituents, makes it an essential intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and receptor modulator research.
• Agrochemical Synthesis: Used in the design and production of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the indole core and halogen substituents.
• Material Science Research: Serves as a precursor for organic electronic materials, such as OLEDs and semiconductors, where the trifluoromethyl group can influence charge transport properties.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological pathways and protein interactions.
• Cross-Coupling Reactions: The bromine atom provides an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl structures.
• Fluorine Chemistry: Acts as a valuable substrate for further functionalization, exploring the unique effects of fluorine atoms in medicinal and materials chemistry.

Basic Information

Product Name	7-Bromo-4-(Trifluoromethyl)-1H-Indole
CAS No.	1260649-67-9
Molecular Formula	C9H5BrF3N
Molecular Weight	264.04 g/mol
Synonyms	7-Bromo-4-(trifluoromethyl)indole; 4-(Trifluoromethyl)-7-bromo-1H-indole; 1H-Indole, 7-bromo-4-(trifluoromethyl)-; 7-Bromo-4-trifluoromethylindole; 7-Br-4-CF3-1H-Indole; 4-Trifluoromethyl-7-bromoindole; 7-Bromo-4-(trifluoromethyl)-1H-indole; 1260649-67-9
EINECS	Contact for details

Quality Control

Our 7-Bromo-4-(Trifluoromethyl)-1H-Indole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity building blocks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.