Description

Ethyl 6-Bromo-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its brominated tetrahydroisoquinoline core structure. This compound is of significant value for its role as a key building block in the synthesis of complex bioactive molecules, offering precise chemical functionality for downstream modifications. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and development services for the global pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for the study of heterocyclic chemistry and the development of new synthetic methodologies.

Basic Information

Product Name	Ethyl 6-Bromo-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate
CAS No.	1260644-50-5
Molecular Formula	C₁₂H₁₄BrNO₂
Molecular Weight	284.15 g/mol
Synonyms	6-Bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid ethyl ester; Ethyl 6-bromo-3,4-dihydro-1H-isoquinoline-1-carboxylate; 1-Carbethoxy-6-bromo-1,2,3,4-tetrahydroisoquinoline; 6-Bromo-1-ethoxycarbonyl-1,2,3,4-tetrahydroisoquinoline; 6-Bromotetrahydroisoquinoline-1-carboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 6-Bromo-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.