Description

6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is a high-value, synthetically versatile heterocyclic building block. This compound is a critical intermediate in the research and development of novel pharmaceutical agents, particularly in the fields of central nervous system (CNS) and cardiovascular therapeutics. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, especially those targeting neurological and cardiovascular pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new bioactive molecules.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes for active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and receptor interactions.
• Custom Synthesis: A foundational component for the custom manufacturing of specialized fine chemicals and advanced intermediates.

Basic Information

Product Name	6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid
CAS No.	1260644-33-4
Molecular Formula	C10H10ClNO2
Molecular Weight	211.65 g/mol
Synonyms	6-Chloro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 1-Carboxy-6-chloro-1,2,3,4-tetrahydroisoquinoline; 6-Chloro-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid; 6-Chloro-THIQ-1-carboxylic Acid; 6-Cl-THIQ-1-COOH; (6-Chloro-3,4-dihydro-1H-isoquinolin-1-yl)formic acid; 1260644-33-4
EINECS	Contact for details

Quality Control

Our 6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.