Description

6-Bromo-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is a high-value brominated tetrahydroisoquinoline derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in providing a versatile, functionalized scaffold for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity building blocks for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Scaffold: Used to explore structure-activity relationships (SAR) by introducing various substituents at the carboxylic acid and bromine positions.
• Protease Inhibitor Development: Serves as a precursor for compounds targeting enzymes like renin, thrombin, and other serine proteases.
• Agrochemical Synthesis: An intermediate in the creation of advanced pesticides and herbicides with specific biological activity.
• Ligand Synthesis for Catalysis: Used to prepare chiral ligands for asymmetric synthesis and metal-organic frameworks (MOFs).
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and the development of new synthetic routes.

Basic Information

Product Name	6-Bromo-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid
CAS No.	1260643-32-0
Molecular Formula	C₁₀H₁₀BrNO₂
Molecular Weight	256.10 g/mol
Synonyms	6-Bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 1,2,3,4-Tetrahydro-6-bromoisoquinoline-1-carboxylic acid; 6-Bromo-THIQ-1-COOH; 6-Bromo-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid; 6-Bromotetrahydroisoquinoline-1-carboxylic acid; 6-Bromo-1-carboxy-1,2,3,4-tetrahydroisoquinoline; (6-Bromo-3,4-dihydro-1H-isoquinolin-1-yl)formic acid
EINECS	Contact for details

Quality Control

Our 6-Bromo-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.