Description

2-(4-Chloro-Phenyl)-6-Methoxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate belonging to the tetrahydroisoquinoline class of compounds. This compound matters as a critical building block for the synthesis of complex molecules, offering a defined chiral center and functional groups essential for modern medicinal chemistry. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• API Synthesis: Serves as a crucial precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for exploratory synthetic chemistry.
• Process Chemistry Development: Supports scale-up and route scouting for efficient and cost-effective manufacturing processes.

Basic Information

Product Name	2-(4-Chloro-Phenyl)-6-Methoxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid
CAS No.	1260643-11-5
Molecular Formula	C17H16ClNO3
Molecular Weight	317.77 g/mol
Synonyms	6-Methoxy-2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 2-(4-Chlorophenyl)-6-methoxy-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid; (1S)-2-(4-Chlorophenyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (enantiomer); Tetrahydroisoquinoline-1-carboxylic acid derivative; CAS 1260643-11-5
EINECS	Contact for details

Quality Control

Our 2-(4-Chloro-Phenyl)-6-Methoxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for demanding pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.